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    Biosynthetic Pathways in Mutations

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    You have isolated four different mutants unable to synthesize compound E required
    for growth. You know that compounds A through D are involved in the biosynthetic
    pathway that produces compound E, but you do not know the order in which they are
    synthesized by a wild-type cell. You supplement the growth of each of the 4 mutants
    with each compound and assay its ability to support growth. Using the data below,
    construct a biochemical pathway indicating the order of the compounds and the step
    where each mutation is acting. Explain how you arrived at the map.

    Compound added
    A B C D E
    1 − − − − +
    2 − + + + +
    3 − − + + +
    4 − − + − +

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    Solution Preview

    First, in all mutations, E could not be synthesized. Therefore, E is the end product of the pathway.
    For mutation 2, compound A is not affected, while B,C,D,E are affected. Therefore, A is in the ...

    Solution Summary

    Biosynthetic pathways in mutations are examined.