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Protein translation and the ER

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1. Describe what type of ER targeting signal sequences each of the following proteins would need for proper translation and localization:
A) A protein that functions in the lumen of the ER
B) An integral membrane protein with 3 membrane spanning domains with SS at its N terminus
C) An integral membrane protein where the first start transfer sequence is not an N-terminal signal sequence

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Solution Summary

Several paragraphs with web references examining the sequences needed to ensure proper protein translation involving the endoplasmic reticulum.

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1. Describe what type of ER targeting signal sequences each of the following proteins would need for proper translation and localization:
A) A protein that functions in the lumen of the ER
In order to first enter into the ER during translation a protein must possess a signal sequence. In addition, proteins that must be retained in the ER contain a KDEL (lysine, aspartic acid, glutamic acid and leucine) signal.

B) ...

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