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Protein translation and the ER

1. Describe what type of ER targeting signal sequences each of the following proteins would need for proper translation and localization:
A) A protein that functions in the lumen of the ER
B) An integral membrane protein with 3 membrane spanning domains with SS at its N terminus
C) An integral membrane protein where the first start transfer sequence is not an N-terminal signal sequence

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1. Describe what type of ER targeting signal sequences each of the following proteins would need for proper translation and localization:
A) A protein that functions in the lumen of the ER
In order to first enter into the ER during translation a protein must possess a signal sequence. In addition, proteins that must be retained in the ER contain a KDEL (lysine, aspartic acid, glutamic acid and leucine) signal.

B) ...

Solution Summary

Several paragraphs with web references examining the sequences needed to ensure proper protein translation involving the endoplasmic reticulum.

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