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    Nuclear Transport Mechanisms

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    What is the mechanism for nuclear transport?

    © BrainMass Inc. brainmass.com October 9, 2019, 6:11 pm ad1c9bdddf

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    Background and Significance
    The nuclear envelope establishes an essential regulatory barrier by which eukaryotic cells can
    control access to the nuclear genome. Gene regulatory signals are transduced into the nucleus
    through the import of specific regulatory proteins. Many of these nuclear proteins contain a
    "classical" nuclear localization signal (NLS). Extensive study of this nuclear transport
    pathway has identified a number of component proteins essential for efficient import of the NLSsubstrate
    into the nucleus. A heterodimeric nuclear transport receptor (importin a/importin b)
    and Ran were originally identified using an in vitro permeabilized cell system. They were shown
    to be essential for nuclear import of NLS-substrate . ...

    Solution Summary

    Nuclear transport mechanisms are determined.