Why does fluoracetate cause citrate to build up in the Citric Acid Cycle? Why do glucose and glycolysis decrease and hexose increases? Why is it fatal? What about fluoroacetyl-SCoA instead in the CAC? Why is it blocking or inhibiting?© BrainMass Inc. brainmass.com March 21, 2019, 1:54 pm ad1c9bdddf
THE MECHANISM OF ACTION OF THE TOXIN FLUOROACETATE
In the body, fluoroacetate is converted to fluorocitrate. This is done through the intermediate fluoroacetyl-CoA. Fluoroacetyl-CoA is made from fluoroacetate by acetate kinase and phosphotransacetylase. When fluoroacetyl-CoA combines with oxaloacetate through the action of the enzyme citrate synthase, fluorocitate is produced. When fluorocitrate builds up, it competes against citrate for the active site of aconitase. Aconitase is one of the necessary ...
The solution discusses the buildup of fluoracetate in the citric acid cycle.