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    Fate of Carbon in Glycolysis

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    I am approaching this problem on paper with the "colored pencil method" for following certain labelled carbon atoms (13C). I have done research online to find a clear representation of the cycle, and both glucose and pyruvate structure. I am hoping that you might be able to follow carbon through the glycolytic pathway and explain some of your approaches to doing this. The problems that follow this sequence involve greater tracking skills and logic.

    1. In which carbon atoms of pyruvate would 13C be found if glucose metabolized by the glycolytic pathway were labeled with 13C at: (a) C1; (b) C4; (c) C6? (Assume that triose phosphate isomerase is able to equilibrate dihydroxyacetone phosphate and gylceraldehyde- 3-phosphate).

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    Solution Summary

    This solution includes explanations and drawn diagrams of atomic structures.