A solution for Allosterity and Cooperativity
Not what you're looking for?
1. Explain in your own words why increasing the hydrophobicity of a drug leads to "entropic optimization" of the binding affinity. Please consider all of the entropic changes that occur in drug binding and how they alter affinity.
2. What are the limitations of this approach to affinity optimization?
3. Please identify some other examples of the practical application of the entropy/enthalpy compensation principle.
Purchase this Solution
Solution Summary
The solubility of drug molecules contributes to their affinity to bind to protein receptor sites of action.
This solution explains the relation between entropy optimization, hydrophobicity and entropy and provides practical examples of the use of this principle in drugs that are available in the market.
The student is invited to reead further on the references proposed.
Solution Preview
Hello,
Please find below the solution to the problem on Allosterithy and Cooperativity in a point form guide for you to expand on.
Feel free to come back with any questions for clarification.
If you are happy with the solution kindly remember to give a rating e.g 5
Thank You for using BrainMass
A solution for Allosterity and Cooperativity
Background
When a compound made up of non-polar molecules is mixed with an aqueous solvent such as water, the molecules cluster together into a ball while water tends to form a ring around them. They do so because they are hydrophobic (. Wikibooks 2015).
When more of this solute is added, the water ring is disturbed as more of the hydrophobic molecules join the non-polar core and the displaced water molecules are freed to move around. This causes high disorder in the solution environment referred to as high entropy.
According to the 2nd Law of Thermodynamics, "The total entropy of the system plus its surrounding must always be ...
Purchase this Solution
Free BrainMass Quizzes
Light and Sight Vocabulary
This quiz introduces basic definitions of vocabulary related to light and how human eyes. This information is important for an understanding of sight.
Biochemistry Basics
A refresher quiz to test your knowledge of basics concepts of biochemistry.
Breastfeeding Basics
How much do you know about breastfeeding? Find out with this quiz!
Identifying Variables in Science Experiments, Part 2
Using sample experiments, test yourself to see if you can identify independent, dependent, and controlled variables. Identifying variables is key in understanding and developing experiments. The questions are biology related, but this can be applied to any area of science.
Basic Immunology Quiz
Intro to immuno quiz. Covers the basics of immunology and recognition of foreign substances by the body.