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Article Review

After reading and going through the article, please help in answering questions below. Thank you.

Please see the attached files.

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Here are the questions you need to address in your review:
1. What are research questions that the authors tried to answer? Could you put them in a set of hypotheses?
2. What is the population of interest?
3. Describe the sample that the authors/researchers collected for the study?
4. What statistical methods were applied by the authors?
5. What was the conclusion of the paper?

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Let's take a closer look:

1. What are research questions that the authors tried to answer? Could you put them in a set of hypotheses? (6 points)

The purpose of the study was to determine whether endothelin-1 contributes to elevated blood pressure in patients with essential hypertension by assessing the effect of four weeks of treatment with bosentan on blood pressure and heart rate.
In addition, the effect of endothelin-receptor antagonism with bosentan on cardiovascular neurohormonal status was examined.

However, the researchers do not list specific research questions, but yet they we can infer research questions from the purpose of the study:

(a) The primary question is: What is the effect of bosentan, as compared with placebo, in reducing diastolic pressure?

(b) The secondary question is: What is the effect of bosentan, as compared with placebo, in reducing systolic pressure?

Ho: There is no difference between bosentan and a placebo in reducing diastolic pressure.
Ha: There is a significant difference between bosentan and placebo in reducing diastolic pressure.

Ho: There is no difference between bosentan ...

Solution Summary

The article is about the contribution of endothelin-1 to elevated blood pressure in patients with essential hypertension. This solution reviews this article on several dimensions e.g., purpose, research questions, hypotheses, population of interest, sample, methods and conclusions.

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