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The Reed-Sternberg cell

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A 35-year-old man has a small lump in his left cervical area. He did not consult a doctor. After several weeks, he felt several more lumps in the same area. At the same time, he has experienced weight loss, fatigue, and low-grade night fever. His doctor immediately took a biopsy of the lump and found a giant Reed-Sternberg cell.

What would be the diagnosis of this patient?

Identify the stage of the disease for this patient.

Identify how the disease is different from similar diseases.

Discuss the possible treatments for the disease.

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Solution Preview

What would be the diagnosis of this patient?

The Reed-Sternberg cell is used to make a differential diagnosis of Hodgkin's
Lymphoma. Reed-Sternberg cells are characteristic cells found in a patient who already
has Hodgkin's Lymphoma. The appearance of this cell in histology is the differential
difference between Hodgkin's and Non-Hodgkin's Lymphoma
((http://www.medicinenet.com/script/main/art.asp?articlekey=79261);
(http://www.uptodate.com/contents/the-reed-sternberg-cell-and-the-pathogenesis-of-hodgkin-lymphoma).

Hodgkin's Lymphoma is much rarer than Non-Hodgkin's Lymphoma. The
disease peaks in two stages of age groups; 15-35 and those over 55. It is more common in
males, those with a past Epstein Barr infection, compromised immune system and people
who live in North America, Asia and Canada and high socioeconomic backgrounds
(http://www.mayoclinic.com/health/hodgkins-disease/DS00186/DSECTION=risk-
factors). The symptoms are itchy skin, unexplained weight loss, night sweats, ...

Solution Summary

The Reed-Sternberg cell is clearly explained and validated with research.

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