Explore BrainMass
Share

Explore BrainMass

    positional congeners of polychlorinated aromatics

    This content was COPIED from BrainMass.com - View the original, and get the already-completed solution here!

    Why do the geometric dimensions of TCDD make it so toxic? Why is toxicity diminished in other congeners where chlorines are removed from the 2,3,7,8 positions, or when chlorines are added to remaining positions on the rings?

    © BrainMass Inc. brainmass.com October 9, 2019, 10:22 pm ad1c9bdddf
    https://brainmass.com/chemistry/environmental-chemistry/positional-congeners-polychlorinated-aromatics-217911

    Solution Preview

    also as attached HTML with live links for you ease of use

    Why the geometry of TCDD? Simply the bioactivity of any compound tends to be positionally specific, stereospecific even. I worked with PBDEs and know that there is "a" specific congener (of the 209 congners) that has the same positional geometry as thyroxine (a iodated biphenyl hormone).None of the others has the same bioactivity (thus it is a hormonal mimic - but doesn't key the same metabolic reactions as thyroxine - so it functions as an inhibitor - hence it is an ...

    Solution Summary

    A discussion of positional congeners of polychlorinated aromatics and related toxicological effects. Specifically focuses on TCDD and uses PBDEs as analogous example. Contains hyperlinked references

    $2.19