Ketones also undergo the aldol condensation although a successful reaction often requires "enhanced" conditions, as the addition involves an unfavorable equilibrium constant. This is the situation in the reaction in which 4-nitrochalcone is synthesized. With the odds against it, why is the reaction successful in this case?© BrainMass Inc. brainmass.com March 4, 2021, 10:19 pm ad1c9bdddf
In this case, the aldehyde (the para-nitrobenzaldehyde) is especially electrophilic and activated thanks to the ...
Explains why the reaction is successful.