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Ketones and Aldol Condensation

Ketones also undergo the aldol condensation although a successful reaction often requires "enhanced" conditions, as the addition involves an unfavorable equilibrium constant. This is the situation in the reaction in which 4-nitrochalcone is synthesized. With the odds against it, why is the reaction successful in this case?

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Hi there,

In this case, the aldehyde (the para-nitrobenzaldehyde) is especially electrophilic and activated thanks to the ...

Solution Summary

Explains why the reaction is successful.