Ketones also undergo the aldol condensation although a successful reaction often requires "enhanced" conditions, as the addition involves an unfavorable equilibrium constant. This is the situation in the reaction in which 4-nitrochalcone is synthesized. With the odds against it, why is the reaction successful in this case?© BrainMass Inc. brainmass.com October 15, 2018, 3:11 pm ad1c9bdddf - https://brainmass.com/chemistry/chemical-equilibrium/ketones-aldol-condensation-321186
In this case, the aldehyde (the para-nitrobenzaldehyde) is especially electrophilic and activated thanks to the ...
Explains why the reaction is successful.