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    Go to the EPA IRIS data base at http://www.epa.gov/iris/index.html Click on List of IRIS Substances. Select Heptachlor (not the QuickView). Answer the following questions in your own words:

    a. What is meant by oral reference dose?

    b. What types of studies did the EPA use to estimate the oral reference dose? (human, animal, or both?)

    c. What was the adverse effect upon which the Agency based its estimate?

    d. What are the major uncertainties in the estimate?

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    Solution Preview

    The datasheet for heptachlor is available at:

    a. The oral reference dose is the dose received by oral consumption that will not result in negative effects. Also see http://tapseis.anl.gov/glossacro/dsp_wordpopup.cfm?word_id=884

    b. The EPA conducted dose experiments involving treating rats with 0, 1.5, 3, 5, 7, or 10 ppm ...

    Solution Summary

    The expert examines Heptachlor IRIS Databases.