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Multiple myeloma or blood plasma cancer is characterized by increased blood vessel formulation in the bone marrow that is a prognostic factor in survival. One treatment approach used for multiple myeloma is stem cell transplantation with the patient's own stem cells. The following data represent the bone marrow microvessel density for a sample of 7 patients who had a complete response to a stem cell transplant as measured by blood and urine tests. Two measurements were taken: the first immediately prior to the stem cell transplant, and the second at the time of the complete response.

Patient 1 2 3 4 5 6 7
Before 158 189 202 353 416 426 441
After 284 214 101 227 290 176 290

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Step by step method for computing test statistic for paired t test is given in the answer.

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