Multiple myeloma or blood plasma cancer is characterized by increased blood vessel formulation in the bone marrow that is a prognostic factor in survival. One treatment approach used for multiple myeloma is stem cell transplantation with the patient's own stem cells. The following data represent the bone marrow microvessel density for a sample of 7 patients who had a complete response to a stem cell transplant as measured by blood and urine tests. Two measurements were taken: the first immediately prior to the stem cell transplant, and the second at the time of the complete response. Use these data to answer the following questions.
Patient 1 2 3 4 5 6 7
Before 158 189 202 353 416 426 441
After 284 214 101 227 290 176 290
Perform an appropriate test of hypothesis to determine if there is evidence, at the .05 level of significance, to support the claim that the mean bone marrow microvessel density is higher before the stem cell transplant than after the stem cell transplant? What is the value of the sample test statistic?
A. z = 1.8424
B. t = 1.8424
C. t = 2.7234
D. p = 2.7234
What is the p-value associated with the test of hypothesis you conducted?
A. p = .057403
B. p = .114986
C. p = .942597
D. p = .885014
At the .01 level of significance, is there sufficient evidence to conclude that the mean bone marrow microvessel density is higher before the stem cell transplant than after the stem cell transplant?
C. It is impossible to determine
The solution provides step by step method for the calculation of test statistic for hypothesis testing . Formula for the calculation and Interpretations of the results are also included. Interactive excel sheet is included. The user can edit the inputs and obtain the complete results for a new set of data.