Clinical Trial Investigations Effectiveness
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3. A clinical trial is run to investigate the effectiveness of an experimental drug in reducing preterm
delivery to a drug considered standard care and to placebo. Pregnant women are enrolled and
randomly assigned to receive either the experimental drug, the standard drug or placebo. Women
are followed through delivery and classified as delivering preterm (< 37 weeks) or not. The data
are shown below.
Preterm Delivery = Yes Experimental Drug = 17,Standard Drug = 23 Placebo = 35
Preterm Delivery = No Experimental Drug = 83,Standard Drug = 77 Placebo = 65
Is there a statistically significant difference in the proportions of women delivering preterm among
the three treatment groups? Run the test at a 5% level of significance.
4. Consider the data presented in problem #3. Previous studies have shown that approximately 32%
of women deliver prematurely without treatment. Is the proportion of women delivering
prematurely significantly higher in the placebo group? Run the test at a 5% level of significance.
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Clinical trial investigations effectiveness is examined.
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3. The given data can be summarised as follows:
Yes No Total
Experimental Drug 17 83 100
Standard Drug 23 77 100
Placebo 35 65 100
Total 75 225 300
The hypothesis to be tested is there is statistically significant difference in the proportions of women delivering patterns among the three groups.
This hypothesis can be tested by formulating the following null and alternative hypotheses.
Null hypothesis The delivering pattern and drug ...
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