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    Clinical Trial Investigations Effectiveness

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    3. A clinical trial is run to investigate the effectiveness of an experimental drug in reducing preterm
    delivery to a drug considered standard care and to placebo. Pregnant women are enrolled and
    randomly assigned to receive either the experimental drug, the standard drug or placebo. Women
    are followed through delivery and classified as delivering preterm (< 37 weeks) or not. The data
    are shown below.

    Preterm Delivery = Yes Experimental Drug = 17,Standard Drug = 23 Placebo = 35

    Preterm Delivery = No Experimental Drug = 83,Standard Drug = 77 Placebo = 65

    Is there a statistically significant difference in the proportions of women delivering preterm among
    the three treatment groups? Run the test at a 5% level of significance.

    4. Consider the data presented in problem #3. Previous studies have shown that approximately 32%
    of women deliver prematurely without treatment. Is the proportion of women delivering
    prematurely significantly higher in the placebo group? Run the test at a 5% level of significance.

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    Solution Preview

    Please see the attached file. Contact if you need any clarifications.

    3. The given data can be summarised as follows:

    Yes No Total
    Experimental Drug 17 83 100
    Standard Drug 23 77 100
    Placebo 35 65 100
    Total 75 225 300

    The hypothesis to be tested is there is statistically significant difference in the proportions of women delivering patterns among the three groups.

    This hypothesis can be tested by formulating the following null and alternative hypotheses.
    Null hypothesis The delivering pattern and drug ...

    Solution Summary

    Clinical trial investigations effectiveness is examined.

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