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    Considering the Warfarin Gene

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    Select a clinical problem with a genetic component (i.e. Insulin Dependent Diabetes Mellitus Type I and HLA-DQ) in your area of interest. You can pick an existing paradigm or be creative and speculative. Just pick a gene or loci that has clinical impact for either diagnostic or prognostic reasons. Infectious diseases and most molecular targets are acceptable. This websites might help: http://www.ncbi.nlm.nih.gov/ OR http://gdbwww.gdb.org/gdb/

    You need to prepare a report on this focal problem that includes the following:

    1) Clinical background. The clinical impact in terms of disease processes, current conventional laboratory methodologies used and the need for genetic testing (i.e. what is the appropriate use of the test in the clinical setting). Two to three paragraphs should be sufficient.

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    Solution Preview

    Warfarin is an anticoagulant that is used to prevent thromboembolic events in more than 2 million patients a year with atrial fibrillation, prosthetic heart valves, or history of thrombosis. It is also useful in prevention or recurrence of myocardial infarction. However, warfarin has a low therapeutic index, wide variation in metabolism between individuals that results in variable inter-individual dosage. Determining a proper dose is critical to prevent adverse effects. Dosage variation is dependent on multiple markers such as age, sex, weight and genetic makeup of the patient. Variations in the genotype of cytochrome p450 and Vitamin K reductase complex subunit I control about half the interindividual ...

    Solution Summary

    The following posting discusses the clinical impacts of the Warfarin gene.