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    Substitution Matrix

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    Smith-Walterman Alignment. See attached file for full problem description.

    Suppose two sequences each 1000 amino acids long are aligned with Smith-Waterman alignment using the PAM250 matrix, what is the score for the following alignment:


    Is this a significant alignment score? Y/N

    Briefly justify your answer by either the extreme value distribution or the quick check method.

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