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    Hypothesis Testing of Proportions: Lovastatin

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    Does Lovastatin (a cholesterol-lowering drug) reduce the risk of heart attack? In a Texas study, researchers gave Lovastatin to 2,325 people and an inactive substitute to 2,081 people (average age 58). After 5 years, 57 of the Lovastatin group had suffered a heart attack, compared with 97 for the inactive pill.

    (a) State the appropriate hypotheses.
    (b) Obtain a test statistic and p-value. Interpret the results at ? = .01.
    (c) Is normality assured?
    (d) Is the difference large enough to be important?
    (e) What else would medical researchers need to know before prescribing this drug widely?

    (Data are from Science News 153 [May 30, 1998], p. 343.)

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    Solution Summary

    The solution provides step by step method for the calculation of testing of hypothesis. Formula for the calculation and Interpretations of the results are also included. Interactive excel sheet is included. The user can edit the inputs and obtain the complete results for a new set of data.