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Statistics Multiple Choice

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A recent study was performed to assess the association between regular aspirin use and occurrence of colorectal adenomas (tumors) in patients with a history of such adenomas. (NEJM, 2003) A total of 749 patients were randomized to receive either 81 mg of aspirin daily (377 patients) or a placebo (372 patients). Patients were screened for the presence of new adenomas 3-years after the start of the study. The unadjusted relative risk of developing new adenomas for those in aspirin group relative to the placebo was 0.81. This relative risk was then adjusted for other patient characteristics, including age, sex, and lifetime number of adenomas. Which of the following most likely corresponds to the adjusted relative risk?

a. substantially greater than 0.81
b. about equal to 0.81
c. substantially less than 0.81

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Adjusted relative risks are determined. Colorectal adenomas in patients over a lifetime are examined in the solution.

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C-The adjusted relative risk would be substantially less than 0.81. This is ...

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