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    Muscular Disorders

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    Mrs. Oliver has pain and stiffness in the muscles and tendons of her shoulders, legs, and neck. She also had osteoarthritis. Her discomfort increases when she is stressed. She also suffers from depression.

    What may be the diagnosis?

    What is her substance P level?

    What are other signs and symptoms of her condition?

    What are the available treatments for her condition?

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    Solution Preview

    In patients with osteoarthritis, joint pain increases with increased activity. This leads to "muscle guarding" i.e. an attempt to keep the painful joint immobile. This results in muscle and tendon fatigue and tenderness.

    Evidence of an increase in substance P levels has been equivocal. However, it is generally believed that there is localized intra-articular and plasma/synovial fluid increase in substance P ...

    Solution Summary

    This solution looks at a hypothetical case where a patient suffers from osteoarthritis, identifying her diagnosis, her substance P level and additional signs and symptoms and explaining possible treatment methods.