A steroid molecule is shown in the attachment. I have to explain which of the two is oxidised faster using Cr(VI) reagents.
I've drawn the molecule in 3D and can say that the equatorial OH is more easily attacked than the axial one because the axial OH has axial interaction with Me causing steric hindrance to the incoming reactant. Are there any more reasons?
Your answer is correct. It is clear from the 3D structure that the axial hydroxyl group is hindered more by the Me group as compared to the ...