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Lidocaine and Bonding to Receptors

Draw abbreviated structural formulae of the products of the complete hydrolysis of lidocaine, and identity the functional groups from the first diagram attached.

Lidocaine is thought to bond to receptors in its methylated form. Identify in writing the atoms or groups that could be involved in its bonding to a receptor via hydrogen bonding (only one example) and ionic reaction, found in the second diagram attached.

Give examples of the types of functional groups that need to be present in the receptor sites in order for these forms of bonding to take place (one example from each bonding)

I would like to know if I am on the right track. Thanks!


Solution Preview

Hi Sandie,

Hydrolysing lidocaine should break the amide group into an amine and a carboxylic acid. Without the diagram, I'm not sure about the 'methylated' form of lidocaine, but I can give you the rules to check the sorts of bonding possible: Hydrogen bonding: any electronegative ...

Solution Summary

The solution draws structural formulae for lidocaine's complete hydrolysis, isolating the functional groups in the first diagram, and noting the properties of lidocaine and its bonding to receptors in certain form. Ionic reactions are also looked at, and altogether, an illustration of the properties of these functional groups and ionic bonding establishes how lidocaine bonds to receptors.