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Helicobacter pylori

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Describe Helicobacter pylori. What major enzymes does this organism produce to enable it to survive in the host? How common is an H. pylori infection? What is the age and social distribution of people infected by this organism? Describe in detail the likely pathogenic process. Which gastrointestinal disorders are associated with H. pylori infection? How is H. pylori infection diagnosed? In addition to drug treatment, what lifestyle advice should be given to patients with peptic ulcers?

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The expert describes the Helicobacter Pylori. The major enzymes an organism produces to enable it to survive in the host is determined.

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H. pylori is a bacterium that is capable avoiding acidic environments of the stomach. In order to actually survive in such acidity where many bacteria would simply perish, H. pylori burrows itself into the mucus layer lining the stomach. Unlike other bacteria that less successfully stay in the mucus layer, H. pylori expersses adhesin proteins which allow it to more successfully bind to the epithelial cells, where pH is much closer to neutral. It also expresses hydrogenase, which oxidizes H2 released by other bacteria in order to harness energy. Most importantly, urease is expressed to convert urea into ammonia, which upon accepting a proton in an acidic environment, becomes ammonium, ...

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