Effect of sickle celled shape on sedimentation rate

Related BrainMass Solutions

• Erythrocyte Sedimentation Rate (ESR) Questions

  b) Red blood cells with an abnormal or irregular shape, such as sickle cells, hinder rouleaux formation, which decreases the ESR.

• RBC

  When sickle cell RBCs give up oxygen in the capillaries, they undergo a change of shape into a sickle shape. This is caused by a polymerization of hemoglobin within the sickle cell RBC.

• Sicle Cell Anemia in African and Middle Eastern Decent

  The sickle cell trait results in red blood cells that are no longer of the normal shape, instead they are elongated ("sickle" shaped).

• ESR: Erythrocyte Sedimentation Rate Test

  The erythrocyte sedimentation rate (ESR) is a test to measure non-specific inflammation. RBCs sediment at varying rates depending on how much fibrinogen is in the blood.

• Various Biological and Organic Chemistry Questions

  The effect of sickle cell anaemia can be dwindle by hydroxyurea which stimulates production of fetal hemoglobin which does not have the complications of sickle cell mutation.

• What are genetics & how does sickle cell disease affect a person

  These fibers or rods, distort the shape of the red blood cells into sickle shaped which impedes the travel of the red blood cells and can cause the organs and tissues to become deprived of oxygen (Figure 1) (Genetic Science Learning Center, 1969).

• Sickle cell disease

  These fibers or rods, distort the shape of the red blood cells into sickle shaped which impedes the travel of the red blood cells and can cause the organs and tissues to become deprived of oxygen (Genetic Science Learning Center, 1969).

• Clinical background to sickle cell anemia

  This occurs under conditions of deoxygenation (low oxygen), individuals who are homozygous HbS, causes the red blood cells to distort their shape into stiff sickle shape cells.

• Sickle Cell Disease (SCD)

  These defective hemoglobin form polymers under low oxygen (hypoxic) environment which makes the red blood cells (RBC) to have a "Sickle" or "Crescent" shape.