Explore BrainMass

Potential problems with transgenic mouse strains.

You have created 3 independent mouse strains carrying the same transgene by non-targeted transgenesis. All 3 strains have otherwise identical genetic backgrounds, yet all 3 have different phenotypes. What are potential explanations for this phenotypic variability?

Solution Preview

1. The transgene may have been mutated at some point in the process.

2. The transgene ...