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DNA Mutation Sequences and Their Impact on DNA replication

1. What is the mutation, how does this mutation impact DNA replication?
2. How was the relationship between the mutation and the disease discovered?
3. What are the symptoms of the disease?
4. How does the problem in DNA replication lead to the symptoms of the disease (a discussion of transcription and/or translation may be appropriate here)?
5. How could genetic engineering technology be used to learn more about this disease?

Solution Preview

1. A mutation is a change in the DNA sequences. There are several types of mutation. A point mutation is a change from one base to another. For example, a TTTTTAAA sequence may be mutated by changing its sequence to TTTGGTTAAA. A frameshift mutation usually is a deletion of a group of sequences that will shift the sequence forward. A deletion mutation will delete base of the sequence. It can impact DNA replication because mutations can cause the DNA polymerase to stalled at the fork because it cannot recognized the mutated bases on the template because of a deletion or gaps in the mutated site. This will lead to errors in DNA replications. An insertion mutation insert a new sequence into the growing chain of DNA.

2. The ...

Solution Summary

A mutation is a change in the DNA sequences. There are several types of mutations. A point mutation is a change from one base to another. For example, a TTTTTAAA sequence may be mutated by changing its sequence to TTTGGTTAAA. A frameshift mutation usually is a deletion of a group of sequences that will shift the sequence forward. An insertion mutation inserts a new sequence into the growing chain of DNA.

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