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Protein Alpha Subunit Mutation

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If the G protein alpha subunit has a mutation so that it can't hydrolyze GTP, what happens?. If the G-protein can only bind to GDP how would that effect the pathway?

I believe if the alpha subunit has a mutation and cant hydrolyze GTP then the G-protein will be unable to inactivate itself. How will this be bad?

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Solution Summary

The expert examines protein alpha subunit mutations. The mutations which cannot hydrolyze GTP then the G-protein will be unable to inactivate itself is determined.

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G proteins are heterotrimers. The alpha subunit acts as the signal transduction molecule when it binds GTP and dissociates from the trimer. After a short while, when GTP hydrolyzes to GDP and Pi, it reverts back to the inactive form (heterotrimeric) form. In other words, the active ...

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