Explain the following recordings in terms of neurotransmitters, neurotransmitter receptors or other mechanisms that we have discussed in class, including voltage-gated channels. There may be multiple explanations for each set of recordings, and you should suggest experimental manipulations you can perform to prove or disprove each hypothesis.
Need your help with this homework. Do not know how to start each one of these problems. I need some solid help/hints/clues to get these problems going.
See attached file for full problem description.
To start out with it would be good to make a list of all the ways to transmit an action potential or change the polarization of a cell (basically we are talking about signaling events that will affect the ion balance of the cells). This includes neurotransmiters, receptors, channels, gates etc.
Here are a few basic references:
Now let's make that list (action or effect on ion transport):
-Acetylcholine is a neuromodulator and excitor (can block K+ release from the cell)
-Norepinephrine can both excite and inhibit depending on which adrenergic receptor it interacts with (increases intracellular Ca+2 levels from endoplasmic reticulum, regulate K+ and Ca+2 channels)
-Dopamine also excitory and inhibitory depending ...